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Positive deletion- and reconstituted- strains were screened by Southern analysis (Figure S1) and DIG-hybridisation probes were generated using primers ogliT-5 and ogliT-4

Numerous ex vivo organ culture studies and large animal models, including rats, rabbits, dogs, and pigs, have demonstrated that minimally invasive injection or percutaneous implantation of hydrogels loaded with transforming growth factor-3, anti-apoptotic miRNA, or autologous mesenchymal stem cells can maintain IVD height, restore its viscoelastic storage modulus, and delay or even partially reverse tissue degeneration (Yang S

is developing next-generation proteasome inhibitors with a high degree of selectivity, with the goal of increasing therapeutic efficacy and reducing side effects

Moreover, alteration of the administration order of Bu-Cy to Cy-Bu gives the same engraftment outcome but reduces the toxicity of the conditioning regimen both in patients and mice 59,60